Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease
Identifieur interne : 002525 ( Main/Exploration ); précédent : 002524; suivant : 002526Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease
Auteurs : Jason Netland [États-Unis] ; Marta L. Dediego [Espagne] ; Jincun Zhao [États-Unis] ; Craig Fett [États-Unis] ; Enrique Álvarez [Espagne] ; José L. Nieto-Torres [Espagne] ; Luis Enjuanes [Espagne] ; Stanley Perlman [États-Unis]Source :
- Virology [ 0042-6822 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Cellules Vero, Humains, Immunité cellulaire (immunologie), Immunité humorale (immunologie), Lymphocytes T CD8+ (immunologie), Modèles animaux de maladie humaine, Mutation, Protéines de l'enveloppe virale (physiologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Test ELISA, Vaccins atténués (usage thérapeutique), Virus du SRAS (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Immunité cellulaire, Immunité humorale, Lymphocytes T CD8+, Syndrome respiratoire aigu sévère, Virus du SRAS.
- physiologie : Protéines de l'enveloppe virale.
- usage thérapeutique : Vaccins atténués.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Humains, Modèles animaux de maladie humaine, Mutation, Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère, Test ELISA.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (immunology), CD8-Positive T-Lymphocytes (immunology), Chlorocebus aethiops, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Immunity, Cellular (immunology), Immunity, Humoral (immunology), Mice, Mice, Inbred BALB C, Mutation, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (virology), Vaccines, Attenuated (therapeutic use), Vero Cells, Viral Envelope Proteins (physiology).
- MESH :
- chemical , immunology : Antibodies, Viral.
- immunology : CD8-Positive T-Lymphocytes, Immunity, Cellular, Immunity, Humoral, SARS Virus, Severe Acute Respiratory Syndrome.
- chemical , physiology : Viral Envelope Proteins.
- prevention & control : Severe Acute Respiratory Syndrome.
- chemical , therapeutic use : Vaccines, Attenuated.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Mice, Mice, Inbred BALB C, Mutation, Vero Cells.
Abstract
The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002–2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-ΔE or SARS-CoV-Δ[E,6-9b] (deleted in accessory proteins (6, 7a, 7b, 8a, 8b, 9b) in addition to E) nearly completely protected BALB/c mice from fatal respiratory disease caused by mouse-adapted SARS-CoV and partly protected hACE2 Tg mice from lethal disease. hACE2 Tg mice, which express the human SARS-CoV receptor, are extremely susceptible to infection. We also show that rSARS-CoV-ΔE and rSARS-CoV-Δ[E,6-9b] induced anti-virus T cell and antibody responses. Further, the E-deleted viruses were stable after 16 blind passages through tissue culture cells, with only a single mutation in the surface glycoprotein detected. The passaged virus remained avirulent in mice. These results suggest that rSARS-CoV-ΔE is an efficacious vaccine candidate that might be useful if SARS recurred.
Url:
DOI: 10.1016/j.virol.2010.01.004
PubMed: 20110095
PubMed Central: 2830353
Affiliations:
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Dediego</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Microbiology, University of Iowa, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Microbiology, University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Microbiology, University of Iowa, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Microbiology, University of Iowa, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Alvarez, Enrique" sort="Alvarez, Enrique" uniqKey="Alvarez E" first="Enrique" last="Álvarez">Enrique Álvarez</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Nieto Torres, Jose L" sort="Nieto Torres, Jose L" uniqKey="Nieto Torres J" first="José L." last="Nieto-Torres">José L. Nieto-Torres</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnolgia (CSIC), Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid</wicri:regionArea><placeName><region nuts="2" type="communauté">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="2"><nlm:aff id="aff1">Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Interdisciplinary Program in Immunology, University of Iowa, Iowa City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Microbiology, University of Iowa, Iowa City, IA 52242</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>Department of Microbiology, University of Iowa, Iowa City</wicri:cityArea></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Chlorocebus aethiops</term><term>Disease Models, Animal</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immunity, Cellular (immunology)</term><term>Immunity, Humoral (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mutation</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Vaccines, Attenuated (therapeutic use)</term><term>Vero Cells</term><term>Viral Envelope Proteins (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Cellules Vero</term><term>Humains</term><term>Immunité cellulaire (immunologie)</term><term>Immunité humorale (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Mutation</term><term>Protéines de l'enveloppe virale (physiologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Test ELISA</term><term>Vaccins atténués (usage thérapeutique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Lymphocytes T CD8+</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins atténués</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Disease Models, Animal</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mutation</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Mutation</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The severe acute respiratory syndrome coronavirus (SARS-CoV) caused substantial morbidity and mortality in 2002–2003. Deletion of the envelope (E) protein modestly diminished virus growth in tissue culture but abrogated virulence in animals. Here, we show that immunization with rSARS-CoV-ΔE or SARS-CoV-Δ[E,6-9b] (deleted in accessory proteins (6, 7a, 7b, 8a, 8b, 9b) in addition to E) nearly completely protected BALB/c mice from fatal respiratory disease caused by mouse-adapted SARS-CoV and partly protected hACE2 Tg mice from lethal disease. hACE2 Tg mice, which express the human SARS-CoV receptor, are extremely susceptible to infection. We also show that rSARS-CoV-ΔE and rSARS-CoV-Δ[E,6-9b] induced anti-virus T cell and antibody responses. Further, the E-deleted viruses were stable after 16 blind passages through tissue culture cells, with only a single mutation in the surface glycoprotein detected. The passaged virus remained avirulent in mice. These results suggest that rSARS-CoV-ΔE is an efficacious vaccine candidate that might be useful if SARS recurred.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bergmann, C C" uniqKey="Bergmann C">C.C. Bergmann</name></author><author><name sortKey="Lane, T E" uniqKey="Lane T">T.E. Lane</name></author><author><name sortKey="Stohlman, S A" uniqKey="Stohlman S">S.A. Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cameron, M J" uniqKey="Cameron M">M.J. Cameron</name></author><author><name sortKey="Ran, L" uniqKey="Ran L">L. Ran</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L. Xu</name></author><author><name sortKey="Danesh, A" uniqKey="Danesh A">A. Danesh</name></author><author><name sortKey="Bermejo Martin, J F" uniqKey="Bermejo Martin J">J.F. Bermejo-Martin</name></author><author><name sortKey="Cameron, C M" uniqKey="Cameron C">C.M. 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Thiel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li><li>États-Unis</li></country><region><li>Communauté de Madrid</li><li>Iowa</li></region></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name></region><name sortKey="Fett, Craig" sort="Fett, Craig" uniqKey="Fett C" first="Craig" last="Fett">Craig Fett</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Dediego, Marta L" sort="Dediego, Marta L" uniqKey="Dediego M" first="Marta L." last="Dediego">Marta L. Dediego</name></region><name sortKey="Alvarez, Enrique" sort="Alvarez, Enrique" uniqKey="Alvarez E" first="Enrique" last="Álvarez">Enrique Álvarez</name><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name><name sortKey="Nieto Torres, Jose L" sort="Nieto Torres, Jose L" uniqKey="Nieto Torres J" first="José L." last="Nieto-Torres">José L. Nieto-Torres</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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